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. 2024 Nov 27;15:1496657. doi: 10.3389/fphar.2024.1496657

FIGURE 5.

FIGURE 5

mIPSC recordings were used to measure GABABR function in NAc cells from wild-type and Rab10-deficient mice. (A) mIPSC record of wild-type (WT, Nestin+; Rab10 +/+) and Rab10-deficient (Nestin+; Rab10 F/F ) mice at −70 mV under saline treatment. (B, C) Quantification of the mIPSC amplitude and frequency. (D) 10%–90% rise time. (E) Decay constant. (F) mIPSC record of wild-type (WT, Nestin+; Rab10 +/+) and Rab10-deficient (Nestin+; Rab10 F/F ) mice at −70 mV under cocaine treatment. (G, H) Quantification of the mIPSC amplitude and frequency recorded under cocaine treatment. (I) 10%–90% rise time. (J) Decay constant. (K) Real-time measurement of the GCaMP6 fluorescence intensity in NAc neurons, following cocaine and/or baclofen treatment. (L) Bar graphs quantifying the GCaMP6 fluorescence intensity in NAc neurons following cocaine treatment. (M) Bar graphs quantifying the GCaMP6 fluorescence intensity in NAc neurons following cocaine + baclofen treatment. Data were presented as the means ± SEM. *p < 0.05; ***p < 0.001; n.s., no significance.