FIGURE 5.
Depiction of the significant results for the radial arm water maze for female and male mice. (A) Depiction of the significant day by drinking history interaction for time taken to complete the maze for female 9M mice, reflecting a longer time taken by water‐drinking versus binge‐drinking females on day 4. (B) Depiction of the same interaction for the 12M females, reflecting a longer time taken by binge‐drinking versus water controls on day 3. (C) Depiction of the significant day by age by drinking history interaction was observed for the time taken by male mice to complete the radial arm maze for which 6M binge‐drinking males completed the maze more quickly on days 2, 6 and 7 versus their water controls. A significant day by age × drinking history interaction for number of reference memory errors was detected in female mice that reflected (D) a significant day by drinking history interaction for the 9M females. A three‐way interaction was also detected for this variable in males that reflected (E) less errors by 12M binge‐drinking males on day 5 compared to water‐drinking controls. A significant day by age by drinking history interaction for the number of working memory correct errors was also detected in females that (F) more errors by 12M binge‐drinking females versus their water controls on day 3. (G) Depiction of the significant day by drinking history interaction was observed for the number of working memory incorrect errors in the 12M females, with binge‐drinking females committing more errors than water controls on day 3. (H) A depiction of the significant day by age interaction for this variable in males, reflected more errors by 6M versus 9M mice on days 2 and 4, while on day 3, 12M mice committed the most errors and on day 7, 9M mice committed more errors than the 12M mice. Figures show means ± SEMs. *p < 0.05, EtOH versus H2O; # p < 0.05, age difference.