TABLE 4.

Summary of the differential protein expression patterns organized by age groups across various brain regions.

A	Glutamate‐related proteins—all brain regions
	Entorhinal cortex (EC)			Prefrontal cortex (PFC)			Amygdala (AMY)
	6M	9M	12M	6M	9M	12M	6M	9M	12M
mGlu1	EtOH M > H2O M EtOH M > EtOH F			EtOH > H2O			EtOH F > H2O F EtOH F > EtOH M		EtOH > H2O
mGlu5 Dimer							EtOH F > H2O F EtOH F > EtOH M	H2O > EtOH	EtOH F > H2O F EtOH F > EtOH M
mGlu5 Monomer		H2O > EtOH	EtOH > H2O	EtOH > H2O	EtOH M < EtOH F EtOH M < H2O M
GluN1			EtOH M > H2O M EtOH M > EtOH F		EtOH < H2O
GluN2B		EtOH M < H2O M EtOH M < EtOH F	EtOH M > H2O M EtOH M > EtOH F	EtOH > H2O	EtOH F < H2O F EtOH F < EtOH M			H2O > EtOH
Homer 1b/c				EtOH > H2O					EtOH > H2O
Homer 2a/b			EtOH > H2O	EtOH > H2O
ERK			EtOH F < H2O F EtOH F < EtOH M	EtOH > H2O					H2O > EtOH
pERK		EtOH M > H2O M EtOH M > EtOH F		EtOH > H2O		EtOH F > EtOH M	EtOH > H2O		H2O > EtOH

B	Neuropathological protein expression—all brain regions
Tau							H2O > EtOH		EtOH > H2O
pThr(217) Tau		EtOH M > H2O M EtOH M > EtOH F	EtOH > H2O	EtOH > H2O
pSer(396) Tau		H2O > EtOH				H2O > EtOH		H2O > EtOH	H2O > EtOH
BACE 56 kDa	H2O > EtOH								EtOH > H2O
BACE 70 kDa	H2O > EtOH		EtOH > H2O
APP			EtOH > H2O			EtOH > H2O			EtOH F > H2O F EtOH F > EtOH M EtOH M > H2O M
Aβ		H2O > EtOH							EtOH > H2O