Figure 6.

Mutation signature analyses for top BbF dose (100 mg/kg/day) in bone marrow (A) and liver (B). The original trinucleotide mutation profile is shown on the top left. SigProfilerAssignment used the single base substitution (SBS) signatures of the Catalogue of Somatic Mutations in Cancer (COSMIC) database to reconstruct the signatures. The SBS signatures and their relative contributions are shown on the right. The reconstructed mutation pattern, number of substitutions used for the assignment, and cosine similarity between reconstructed and observed trinucleotide mutation profile are shown on left below the original profile. The total number of mutations in the original signature are indicated on the left.