Abstract
2-Isobutyl-3-methoxypyrazine, a potent bell-pepper odorant, binds to cow olfactory mucosa homogenate. The receptor is saturable in the micromolar range and is competitively inhibited by other bell-pepper odourants, but not by other pyrazines of different odours. Other tissues do not bind 2-isobutyl-3-methoxypyrazine at a significant extent. We suggest that this receptor is involved in odour discrimination.
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Selected References
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- Cagan R. H., Zeiger W. N. Biochemical studies of olfaction: binding specificity of radioactively labeled stimuli to an isolated olfactory preparation from rainbow trout (Salmo gairdneri). Proc Natl Acad Sci U S A. 1978 Oct;75(10):4679–4683. doi: 10.1073/pnas.75.10.4679. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fesenko E. E., Novoselov V. I., Krapivinskaya L. D. Molecular mechanisms of olfactory reception. IV. Some biochemical characteristics of the camphor receptor from rat olfactory epithelium. Biochim Biophys Acta. 1979 Oct 18;587(3):424–432. doi: 10.1016/0304-4165(79)90446-x. [DOI] [PubMed] [Google Scholar]
- Gennings J. N., Gower D. B., Bannister L. H. Studies on the receptors to 5alpha-androst-16-en-3-one and 5alpha-androst-16-en-3alpha-ol in sow nasal mucosa. Biochim Biophys Acta. 1977 Feb 28;496(2):547–556. doi: 10.1016/0304-4165(77)90335-x. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Rhein L. D., Cagan R. H. Biochemical studies of olfaction: isolation, characterization, and odorant binding activity of cilia from rainbow trout olfactory rosettes. Proc Natl Acad Sci U S A. 1980 Aug;77(8):4412–4416. doi: 10.1073/pnas.77.8.4412. [DOI] [PMC free article] [PubMed] [Google Scholar]