Fig. 7.

Statin regulation of patatin‐like phospholipase domain containing 3 (PNPLA3) in primary human HSC required SREBF2. (a and b) Primary human hepatic stellate cells (HSC) were exposed to atorvastatin (Atrov.) or vehicle dimethylsulfoxide (DMSO), with and without SREBF2 knockdown, and the mRNA levels of SREBF2, 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), PCSK9, low‐density lipoprotein receptor (LDLR), and PNPLA3 were quantified using qPCR. Data are expressed as mean ± SEM. One‐way ANOVA, Fisher's least significant difference (LSD) post hoc test. n.s., not significant; siC, scrambled siRNA; siSR, SREBF2 siRNA. **p < 0.01, ***p < 0.001, and ****p < 0.0001 (n = 3–4).