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. 2021 Apr 25;23(10):1612–1676. doi: 10.1093/europace/euab065

NOAC dosing in AF patients post-ACS/PCI (see ‘Patients with atrial fibrillation and coronary artery disease' section)

Standard dose Comments/dose reduction
Apixaban244 5 mg BID Dose reduction as for SPAF
Dabigatran247 150 mg BID or 110 mg BID 110mg as for SPAF403
Edoxaban245 60 mg QD Dose reduction as for SPAF
Rivaroxaban246 15 mg QD Dose reduction to 10 mg QD if CrCl 30–49 mL/min

In addition to single/dual antiplatelet therapy, where applicable. See ‘Patients with atrial fibrillation and coronary artery disease' section for details.

BID, twice daily; CrCl, creatinine clearance; QD, once daily; SPAF, stroke prevention in atrial fibrillation.