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VTE prevention post-major orthopaedic surgery
| Standard dose | Comments/dose reduction | |
|---|---|---|
| Apixaban507 | 2.5 mg BID | |
| Dabigatran508,509 | 220 mg QD/150 mg QD | a |
| Edoxaban510,511 | 30 mg QD | Not approved in Europe (only studied in Asia) |
| Rivaroxaban512–515 | 10 mg QD |
BID, twice daily; QD, once daily.
SmPc: 1× 150 mg if CrCl 30–50 mL/min; concomitant verapamil, amiodarone, quinidine; age >75 years.
