Table III.
Mean (± SD) and median (range) time parameters estimates using the graphical and modeling approaches for Class I/III and Class II/IV drugs listed in Table II
| Model | Temporal parameter | Class I/III | Class II/IV |
|---|---|---|---|
| Graphical | τd (h) |
0.28 (± 0.4)[mean] 0.33 (0.086–1.86)[median] |
- |
| M.D.T. (h) |
0.13 (± 0.06)[mean] 0.109 (0.050–0.373)[median] |
- | |
| M.D.T.s. (h) | - |
2.3 (± 7) [mean] 0.32 (0.027–30) [median] |
|
| Noyes-Whitney | τd (h) |
0.35 (± 0.2)[mean] 0.29 (0.084–0.97)[median] |
- |
| M.D.T. (h) |
0.098 (± 0.05)[mean] 0.083 (0.026–0.24)[median] |
- | |
| M.D.T.s. (h) | - |
2.7 (± 6) [mean] 0.42 (0.018–24) [median] |
|
| Weibull | τd (h) |
0.33 (± 0.16)[mean] 0.29 (0.084–0.88)[median] |
- |
| M.D.T. (h) |
0.11 (± 0.05)[mean] 0.106 (0.031–0.21)[median] |
- | |
| M.D.T.s. (h) | - |
0.27 (± 0.2) [mean] 0.25 (0.018–0.74)[median] |
|
| Reaction-limited | τd (h) | - | - |
| M.D.T. (h) |
0.07917 (± 0.00882) [mean] 0.08093 (0.05143–0.10293) [median] |
- | |
| M.D.T.s. (h) | - |
0.46 (± 0.7)[mean] 0.29 (0.034–3.2)[median] |