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(A) In-vitro dissolution profiles of BSE and BSEN, (B) Ex-vivo permeability profiles of BSE and BSEN, (C) Body weight, (D) Paw Thickness, (E) Paw Volume, (F) TNF-α measurement in mice. Animals were treated with vehicle (control), Arthritic control (FCA-induced arthritis), indomethacin (3 mg/kg), pure BSE (180 mg/kg), and the BSEN (equivalent to BSE 180 mg/kg). Data expressed as mean ± SEM.
