Table 2:

Univariable and Multivariable Linear Regression for the Association between Immune Marker Levels and HAND

Immune Marker	N	n	HAND Category	Univariable		*Multivariable
				MD	P	MD	P
sCD14	149	114	Unimpaired	Ref		Ref
		21	ANI	0.14	0.052	0.17	0.033
		14	MND	0.22	0.013	0.21	0.023
sCD163	149	114	Unimpaired	Ref		Ref
		21	ANI	0.1	0.545	0.04	0.8
		14	MND	0.27	0.185	0.18	0.357
MCP-1	158	120	Unimpaired	Ref		Ref
		25	ANI	0.16	0.176	0.19	0.12
		13	MND	0.26	0.094	0.26	0.103
TNF-α	150	112	Unimpaired	Ref		Ref
		25	ANI	−0.19	0.133	−0.17	0.187
		13	MND	0.23	0.177	0.15	0.373
Neopterin	176	136	Unimpaired	Ref		Ref
		27	ANI	0.14	0.871	0.0004	0.993
		13	MND	0.22	0.068	0.22	0.054

^*Adjusted for age, gender, years of education, CD4 count and viral load,

N: number of participants

MD: Mean Difference

P: P-value

HAND: HIV associated neurocognitive disorders

ANI: Asymptomatic neurocognitive impairment

MND: Mild neurocognitive disorder