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. 2024 Dec 11;12(1):e200340. doi: 10.1212/NXI.0000000000200340

Figure 2. Potential of Complement Factors as Prognostic Biomarkers in Patients With MOGAD.

Figure 2

(A) Kaplan-Meier curves evaluating the time to second relapse in patients with high (>10.8) and low (<10.8) CSF values of the C4a/C4 ratio, revealing a higher risk of second relapse in patients with MOGAD with higher CSF values (log-rank test p value: 0.01). (B) Boxplots depicting the distribution of CSF SC5b9 levels in patients reaching and not reaching an EDSS of 3.0. Median values are represented by the horizontal bar, IQR by hinges, and 1.5 × IQR by whiskers. The comparison analysis (Mann-Whitney test) demonstrated higher CSF SC5b9 levels in patients reaching an EDSS of 3.0 (p = 0.002). (C) Performance of CSF SC5b9 levels (in ng/mL) to discriminate between patients with MOGAD who will and will not reach an EDSS of 3.0. AUC = area under the curve; EDSS = Expanded Disability Status Scale; IQR = interquartile range; MOGAD = MOG-IgG antibody-associated disease; SE = sensitivity; SP = specificity.