Table 3.
Univariable and Multivariable Mixed Linear Models to Test the Association Between Serum and CSF Levels of Complement Factors and EDSS at Last Follow-Up in Patients With MOGAD
| EDSS at last follow-up | ||||
| Serum | CSF | |||
| Factors | Univariable β (95% CI)a; p Value | Multivariable β (95% CI)a; p Value | Univariable β (95% CI)a; p Value | Multivariable β (95% CI)a; p Value |
| Ba | 0.03 (0.0 to 0.10); 0.47 | 0.03 (−0.05 to 0.10); 0.48 | 3.17 (0.70 to 5.64); 0.01 | 0.98 (−1.76 to 3.71); 0.48 |
| Bb | 2.06 (−4.26 to 8.38); 0.52 | −0.63 (−7.28 to 6.03); 0.85 | 9.10 (2.10 to 16.02); 0.01 | 4.12 (−3.56 to 11.80); 0.29 |
| C3a | 0.01 (−0.01 to 0.02); 0.46 | 0.00 (−0.01 to 0.02); 0.59 | 3.69 (1.53 to 5.84); <0.01 | 2.69 (0.45 to 4.93); 0.02 |
| C4a | −0.01 (−0.03 to 0.01); 0.38 | −0.01 (−0.03 to 0.01); 0.23 | 1.76 (0.54 to 2.98); <0.01 | −0.03 (−1.65 to 1.58); 0.97 |
| C5a | −0.08 (−0.69 to 0.53); 0.80 | −0.33 (−0.95 to 0.29); 0.29 | 1.46 (0.66 to 2.26); <0.01 | 0.99 (0.12 to 1.87); 0.03 |
| Factor H | 0.08 (−0.37 to 0.53); 0.74 | 0.18 (−0.36 to 0.72); 0.51 | 4.03 (2.41 to 5.65); <0.01 | 2.68 (0.65 to 4.71); 0.01 |
| Factor I | 0.00 (0.00 to 0.01); 0.52 | 0.00 (0.00 to 0.01); 0.26 | 0.59 (0.33 to 0.84); <0.01 | 0.47 (0.11 to 0.83); 0.01 |
| SC5b9 | 0.00 (−0.01 to 0.01); 0.79 | −0.01 (−0.02 to 0.01); 0.31 | 2.27 (1.24 to 3.29); <0.01 | 1.82 (0.69 to 2.96); <0.01 |
| C1q | −0.36 (−1.82 to 1.10); 0.62 | −0.71 (−2.20 to 0.78); 0.35 | 1.53 (−0.67 to 3.73); 0.17 | 0.41 (−1.89 to 2.72); 0.72 |
| C3 | 0.01 (−0.04 to 0.06); 0.81 | 0.00 (−0.05 to 0.05); 0.98 | 1.76 (−10.45 to 13.98); 0.78 | 1.02 (−10.27 to 12.30); 0.86 |
| C4 | 0.00 (−0.02 to 0.03); 0.88 | 0.00 (−0.03 to 0.03); 0.98 | −0.98 (−9.29 to 7.34); 0.82 | 3.81 (−4.48 to 12.09); 0.36 |
| C5 | 0.36 (−0.78 to 1.50); 0.53 | 0.24 (−0.87 to 1.34); 0.67 | 2.74 (1.11 to 4.38); <0.01 | 1.77 (−0.24 to 3.77); 0.08 |
| C3a/C3 | 1.30 (−0.35 to 2.95); 0.12 | 0.92 (−0.96 to 2.79); 0.33 | 1.65 (0.77 to 2.54); <0.01 | 1.25 (0.37 to 2.14); <0.01 |
| C4a/C4 | 0.62 (−0.54 to 1.78); 0.29 | 0.04 (−1.43 to 1.51); 0.96 | −0.01 (−0.10 to to 0.08); 0.79 | −0.07 (−0.15 to 0.02); 0.12 |
| C5a/C5 | −0.71 (−9.08 to 7.65); 0.87 | −5.39 (−14.36 to 3.58); 0.24 | 0.72 (−0.34 to 1.78); 0.18 | 0.18 (−1.17 to 1.54); 0.79 |
Abbreviation: EDSS = Expanded Disability Status Scale.
a
Coefficients are transformed by multiplying complement values by 100, except for CSF factor H (multiplied by 10) and CSF Bb, C5a, C1q, and C5 (nontransformed). Missing information: n = 8.