Table 4.
Logistic Regression Models to Test the Association Between Serum and CSF Levels of Complement Factors and EDSS ≥ 3.0 at Last Follow-Up in Patients With MOGAD
| EDSS ≥3.0 at last follow-up | ||||
| Serum | CSF | |||
| Factors | Univariable OR (95% CI); p Value | Multivariable OR (95% CI); p Value | Univariable OR (95% CI); p Value | Multivariable OR (95% CI); p Value |
| Ba | 1.08 (0.95–1.26); 0.28 | 1.17 (0.96–1.57); 0.18 | 9.44 (0.15–608.49); 0.28 | 4.79 (0.01–1754.84); 0.60 |
| Bb | 74.79 (0.00–1.49e+6); 0.39 | 1,067.22 (0.00–1.56e+10); 0.38 | (0.00); 0.15 | (0.00); 0.23 |
| C3a | 1.01 (0.98–1.04); 0.65 | 1.02 (0.98–1.08); 0.31 | 19.87 (0.60–3,100.36); 0.14 | 68.48 (0.49–2.32e+5); 0.20 |
| C4a | 0.99 (0.96–1.02); 0.68 | 0.98 (0.92–1.03); 0.50 | 5.19 (0.74–40.39); 0.09 | 1.49 (0.04–47.85); 0.82 |
| C5a | 1.14 (0.40–2.87); 0.79 | 0.98 (0.14–4.05); 0.98 | 7.18e+62 (1,360.39–4.15e+141); 0.07 | 4.37e+64 (0.00–6.62e+168); 0.13 |
| Factor H | 1.23 (0.60–2.45); 0.54 | 1.25 (0.38–4.26); 0.71 | 1.48e+31 (2.57e+8–1.21e+69); 0.05 | 1.96e+24 (0.39–1.55e+74); 0.24 |
| Factor I | 1.00 (0.99–1.01); 0.54 | 1.01 (0.99–1.02); 0.46 | 2.14 (1.22–5.17); 0.04 | 3.18 (1.20–14.02); 0.06 |
| SC5b9 | 1.01 (0.99–1.02); 0.46 | 1.00 (0.97–1.03); 0.80 | 1.54 (1.16–2.51)a; 0.02 | 1.79 (1.16–3.67)a; 0.04 |
| C1q | 1.01 (0.99–1.02); 0.52 | 1.47 (0.07–24.10); 0.79 | 1.33e+34 (0.00–6.21e+173); 0.65 | 1.52e+70 (0.00–2.52e+278); 0.50 |
| C3 | 1.97 (0.19–17.97); 0.55 | 1.05 (0.96–1.17); 0.25 | 80.45 (0.00–6.09e+9); 0.64 | 2,345.17 (0.00–1.62e+13); 0.50 |
| C4 | 1.05 (0.97–1.14); 0.21 | 1.01 (0.95–1.06); 0.78 | 1.64 (0.00–1.58e+6); 0.94 | 3.66e+4 (0.00–3.15e+16); 0.37 |
| C5 | 1.00 (0.95–1.04); 0.87 | 0.81 (0.07–8.47); 0.86 | 2.05e+108 (0.00–1.52e+234); 0.06 | 4.36e+142 (0.00–); 0.13 |
| C3a/C3 | 0.98 (0.15–6.00); 0.98 | 1.92 (0.03–112.78); 0.75 | 4.52 (0.89–112.35); 0.19 | 5.55 (0.72–612.24); 0.29 |
| C4a/C4 | 2.70 (0.19–36.90); 0.44 | 0.01 (0.00–1.88); 0.18 | 0.92 (0.59–1.09); 0.53 | 0.52 (0.03–1.05); 0.56 |
| C5a/C5 | 1.25 (0.16–7.06); 0.81 | 2.00 (0.00–2.06e+08); 0.95 | 1.63 (0.28–7.51); 0.54 | 0.20 (0.00–5.32); 0.48 |
Abbreviations: EDSS = Expanded Disability Status Scale; OR = odds ratio.
a
Coefficients are transformed by multiplying complement values by 10. Missing values are indicated in Table 1.