Table 5.
Mixed Linear Regression Models to Test the Association Between Serum and CSF Levels of Complement Factors and VA at Last Follow-Up in Patients With MOGAD
| Final VA | ||||
| Serum | CSF | |||
| Factors | Univariable estimate (95% CI); p Value | Multivariable estimate (95% CI); p Value | Univariable estimate (95% CI); p Value | Multivariable estimate (95% CI); p Value |
| Ba | −0.01 (−0.03 to 0.00); 0.11 | −0.01 (−0.02 to 0.01); 0.22 | −0.67 (−1.19 to −0.16); 0.01 | −0.62 (−1.13 to −0.12); 0.02 |
| Bb | −0.31 (−1.62 to 1.00); 0.64 | −0.11 (−1.67 to 1.44); 0.88 | −74.35 (−369.46 to 220.77); 0.62 | −78.17 (−354.80 to 198.46); 0.57 |
| C3a | 0.00 (0.00–0.00); 0.56 | 0.00 (−0.01 to 0.00); 0.43 | −0.15 (−1.16 to 0.87); 0.77 | −0.21 −1.17 to 0.76); 0.67 |
| C4a | 0.00 (−0.01 to 0.00); 0.20 | 0.00 (−0.01 to 0.00); 0.14 | −0.24 (−0.64 to 0.16); 0.24 | 0.00 (−0.46 to 0.46); >0.99 |
| C5a | 0.04 (−0.09 to 0.16); 0.55 | 0.07 (−0.07 to 0.21); 0.33 | −31.45 (−56.96 to −5.95); 0.02 | −29.26 (−54.69 to −3.83); 0.03 |
| Factor H | −0.02 (−0.12 to 0.07); 0.64 | −0.02 (−0.15 to 0.12); 0.81 | −2.33 (−11.31 to 6.65); 0.61 | 2.84 (−6.74 to 12.43); 0.55 |
| Factor I | 0.00 (0.00 to 0.00); 0.66 | 0.00 (0.00 to 0.00); 0.82 | −0.10 (−0.22 to 0.02); 0.11 | −0.08 (−0.19 to 0.04); 0.20 |
| SC5b9 | 0.00 (0.00 to 0.00); 0.49 | 0.00 (0.00 to 0.00); 0.54 | −0.14 (−0.74 to 0.46); 0.65 | −0.23 (−0.81 to 0.34); 0.41 |
| C1q | 0.02 (−0.29 to 0.34); 0.89 | 0.11 (−0.23 to 0.46); 0.51 | 12.72 (−43.71 to 69.14); 0.65 | 7.49 (−45.34 to 60.32); 0.78 |
| C3 | −0.01 (−0.02 to 0.00); 0.03 | −0.01 (−0.02 to 0.00); 0.05 | −3.25 (−5.43 to −1.08); <0.01 | −3.34 (−5.44 to −1.23); <0.01 |
| C4 | 0.00 (−0.01 to 0.01); 0.85 | 0.00 (−0.01 to 0.01); 0.54 | 2.02 (0.31 to 3.73); 0.02 | 1.91 (−0.12 to 3.94); 0.06 |
| C5 | −0.23 (−0.49 to 0.03); 0.09 | −0.23 (−0.49 to 0.04); 0.10 | 6.83 (−43.82 to 57.48); 0.79 | 13.38 (−36.02 to 62.78); 0.59 |
| C3a/C3 | 0.05 (−0.27 to 0.37); 0.77 | 0.18 (−0.19 to 0.56); 0.33 | 0.16 (−0.49 to 0.80); 0.63 | 0.13 (−0.50 to 0.77); 0.68 |
| C4a/C4 | −0.16 (−0.38 to 0.07); 0.17 | −0.17 (−0.49 to 0.14); 0.28 | −0.01 (−0.03 to 0.01); 0.24 | −0.01 (−0.03 to 0.01); 0.31 |
| C5a/C5 | 0.66 (−0.89 to 2.21); 0.40 | 1.39 (−0.36 to 3.13); 0.12 | −0.25 (−0.42 to −0.08); <0.01 | −0.37 (−0.58 to −0.16); <0.01 |
Abbreviation: VA = visual acuity.
Missing values are indicated in Table 1.