TABLE 5.
Univariate and multivariate Cox model of variables associated with the risk of ABMR.
| Immunological variables | N | HR | 95% CI | P-value |
|---|---|---|---|---|
| Univariate Cox model | ||||
| Immunodominant DSA maximal MFI, per 1,000 units increase | 45 | 1.08 | 1.01, 1.14 | 0.015 |
| Category of immunodominant DSA maximal MFI <3,000 3,000–10,000 >10,000 |
45 |
— 1.66 3.49 |
— 0.48, 5.75 1.25, 9.76 |
— 0.4 0.017 |
| Immunodominant DSA Day-0 MFI, per 1,000 units increase | 45 | 0.98 | 0.91, 1.07 | 0.7 |
| Sum of DSA MFI, per 1,000 units increase | 45 | 1.02 | 1.01, 1.03 | 0.007 |
| Category of sum of DSA MFI <10,000 >10,000 |
45 |
— 3.35 |
— 1.42, 7.88 |
— 0.006 |
| Number of antigenic mismatches, per unit | 45 | 1.05 | 0.86, 1.28 | 0.6 |
| Presence of repeated antigenic mismatches | 41 | 0.85 | 0.31, 2.31 | 0.8 |
| Number of eplet mismatches, per unit | 45 | 1.03 | 0.98, 1.09 | 0.3 |
| Presence of repeated eplet mismatches | 44 | 0.72 | 0.21, 2.44 | 0.6 |
| Presence of DREMM | 45 | 3.37 | 1.25, 9.06 | 0.016 |
| Presence of class I DREMM | 45 | 2.54 | 1.10, 5.83 | 0.028 |
| Presence of class II DREMM | 45 | 2.00 | 0.87, 4.58 | 0.10 |
| Multivariate Cox Model | ||||
| 1st model | ||||
| Immunodominant DSA maximal MFI, per 1,000 units increase | 45 | 1.05 | 0.98, 1.13 | 0.13 |
| Presence of DREMM | 45 | 2.58 | 0.90, 7.34 | 0.076 |
| 2nd model | ||||
| Sum of DSA MFI, per 1,000 units increase | 45 | 1.01 | 1.00, 1.03 | 0.087 |
| Presence of DREMM | 45 | 2.72 | 0.96, 7.67 | 0.059 |
HR, hazard ratio; CI, confidence interval; DSA, donor specific-antibody; DSA, donor-specific antibody; DREMM, donor-specific antibody targeting a repeated antibody-verified eplet mismatch; MFI, mean fluorescence intensity; Sum of MFI, sum of the MFI of each DSA the day of the maximal MFI of the immunodominant DSA.