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. 2024 Jul 1;31(12):1848–1858. doi: 10.1038/s41594-024-01352-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Analytical SEC traces of mtHsp60^V72I (black) and folded FITC-mtMDH (purple). Solid lines are the A₂₈₀ traces and dashed lines are the A₄₉₅ traces. This experiment was repeated a total of three times with similar results. b, As in a, but for V72I incubated with folded FITC-mtMDH (black) or guanidine-denatured FITC-mtMDH (purple). Note the minimal coelution of mtHsp60 with folded FITC-mtMDH, compared with quantitative coelution with denatured FITC-mtMDH. This experiment was repeated a total of three times with similar results. c, Selected 2D top view class averages from the mtHsp60^apo dataset (upper), showing classes with no or weak client density, and from the dataset with denatured FITC-mtMDH added (lower), showing much stronger client density. Scale bars, 100 Å. mAU, milli-absorbance unit.

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