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. 2024 Jul 10;31(12):1888–1897. doi: 10.1038/s41594-024-01355-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Structure of E. coli DHFR (PDB 5CCC). b, Schematic illustrations of stall-inducing constructs. The stall site is indicated in red, and subdomains are colored gold (discontinuous loop subdomain, DLD) or bronze (adenosine binding subdomain, ABD), with the artificial linker in FL + 58^RNC in black. The region of the NC expected to span the exit tunnel is indicated. PTC, peptidyl transfer center. c, Secondary structure elements in DHFR, colored according to subdomains as in b. Sites where the stall sequence was inserted are marked with arrows.