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. 2024 Jul 10;31(12):1888–1897. doi: 10.1038/s41594-024-01355-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Side view of the 70S ribosome, highlighting ribosomal proteins that line the exit tunnel and vestibule (PDB 3JBU). TF is placed onto the structure based on a previous publication⁵⁶. The structure contains the 17-aa wild-type SecM stall-inducing sequence, although to match the length of the sequence used in this study only eight amino acids are shown. b–g, HDX analysis of ribosomal proteins in RNCs. Peptides that are protected from HDX in each RNC relative to empty ribosomes, at any deuteration time point, are colored blue. Deprotected peptides are colored red. The tunnel-facing loop of L23 is indicated with a green dashed rectangle in b, the TF docking site is indicated with a green dashed rectangle in c and the exposed loop of L24 is indicated with a green dashed rectangle in f. See also Supplementary Data 1.