FIGURE 1.

Schematic representation of experimental design and timeline of sampling. There are 4 sampling days: BAS1 (before experimental RAAS activation with low‐sodium diet), BAS2 (after 5 days of low‐sodium diet), DOS1 (after first dose of CARDALIS®), and DOS14 (after 14 days of dosing with CARDALIS®). Three groups (n = 6 dogs each) received different doses of CARDALIS®. Colored circles indicate purpose and timing of blood samples collected on each sampling day. RAAS, renin‐angiotensin‐aldosterone system.