TABLE 3.

Selected clinicopathologic results in 18 healthy dogs before treatment (BAS2) and after 14 days of CARDALIS® administration (DOS14) at 3 different doses (n = 6 dogs in each dosage group).

		BAS2			DOS14
Variable	Reference range	Label dose q24h	Label dose q12h	Double label dose q12h	Label dose q24h	Label dose q12h	Double label dose q12h
Blood urea nitrogen	10‐30 mg/dL	15.0 (12.8‐16.5)	19.0 (19‐19.8)	17.0 (15.2‐20.0)	9.0 (6.0‐9.8)	11.0 (10.0‐13.0)	10.5 (8.0‐13.8)
Creatinine	0.5‐1.5 mg/dL	0.6 (0.6‐0.6)	0.6 (0.6‐0.7)	0.6 (0.6‐0.7)	0.6 (0.6‐0.6)	0.7 (0.6‐0.7)	0.6 (0.6‐0.8)
Sodium	141‐151 mEq/L	142.5 (142.0‐143.0)	141.5 (141.0‐142.0)	142.5 (141.2‐143.0)	142.5 (142.2‐142.8) n = 2	140.0 (139.5‐140.5) n = 2	138.0 (138.0‐139.5) n = 3
Chloride	112‐121 mEq/L	107.0 (107.0‐107.0)	107.0 (106.2‐107.0)	108.0 (107.2‐108.8)	109.5 (109.2‐109.8) n = 2	109.0 (108.0‐110.5) n = 3	109.5 (108.2‐110.5) n = 4
Potassium	3.9‐5.3 mEq/L	5.0 (4.6‐5.1)	5.0 (4.9‐5.1)	5.0 (4.8‐5.2)	4.5 (4.3‐4.7) n = 2	4.6 (4.5‐4.7) n = 3	4.7 (4.6‐5.1) n = 4
Total protein	5.2‐7.1 g/dL	6.3 (6.1‐6.5)	6.3 (6.1‐6.4)	6.3 (5.9‐6.3)	5.8 (5.5‐6.0)	5.7 (5.5‐6.0) n = 5	5.6 (5.5‐5.8)
Albumin	2.7‐4.0 g/dL	3.8 (3.6‐3.8)	3.5 (3.3‐3.6)	3.5 (3.4‐3.6)	3.0 (2.9‐3.1)	3.2 (2.9‐3.3) n = 5	2.9 (2.8‐3.0)
Hematocrit	37.0‐55.0%	55.3 (52.6‐56.5)	53.9 (51.1‐54.6)	52.0 (51.5‐53.2)	52.8 (48.7‐55.5)	50.3 (46.0‐53.1)	49.5 (48.9‐50.0)

Note: Data are presented as median (interquartile range). Number of dogs is indicated for variables with incomplete datasets because of insufficient volume of blood sampled. CARDALIS® dosage groups: label dose q24h (benazepril 0.25 mg/kg + spironolactone 2 mg/kg PO q24h); label dose q12h (benazepril 0.25 mg/kg + spironolactone 2 mg/kg PO q12h); and double label dose q12h (0.5 mg/kg benazepril + 4 mg/kg spironolactone PO q12h). Reference ranges are provided by the Iowa State University Clinical Pathology Laboratory.