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. 2024 Oct 4;6(12):900–911. doi: 10.1002/acr2.11745

Figure 5.

Figure 5

ABT‐317 reduced phospho‐STAT1 and pSTAT3 expression in the kidneys. Kidneys were collected at the conclusion of the study and stained for pSTAT1 and pSTAT3 to generate histological scores. (A) Representative images of pSTAT3 staining, showing an up‐regulation of pSTAT3 in resident glomerular and tubule epithelial cells, as well as infiltrating immune cells in baseline and vehicle‐treated mice, with reduction of PSTAT3 staining in ABT‐317 and anti‐CD40‐treated mice (B) ABT‐317 significantly reduced expression of pSTAT1 and pSTAT3 in the kidneys of NZB/W‐F1 mice. **P < 0.01 vs vehicle; #P < 0.05 vs baseline using Kruskal‐Wallis statistical test with Dunn's multiple comparisons. pSTAT1, phosphorylated STAT1; pSTAT3, phosphorylated STAT3.