Figure 6.

Gene signature scores in human glomeruli and tubules demonstrate model translatability. Publicly available gene expression data from isolated glomerular and tubular cells from 15 HDs and 32 patients with LN were examined for gene signatures similar to those identified in NZB/W‐F₁ mice. (A) Patients with LN exhibit a significantly elevated IFN signature in glomeruli and tubules compared to HDs. (B) Patients with LN exhibit a significant increase in the JAK1 signature in glomeruli but a significant decrease in JAK1 signature in tubules compared to HDs. (C, D) Nephrotic and injury‐associated up‐ and down‐gene signatures were significantly different between LN glomeruli and tubules compared to HDs. *P < 0.05; **P < 0.01; ****P < 0.0001 vs HDs. HD, healthy donor; IFN, interferon; LN, lupus nephritis.