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. 2024 Nov 29;15:1513076. doi: 10.3389/fimmu.2024.1513076

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Copyright © 2024 Miao, Dong, Zhou, Thiel, Li, Cai, Yuan, Wang, Jin, Yang, Wang, Frey, Gaipl, Ma and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Origin of Str1 tumor cell subpopulations in LG-ESS. (A) RNA velocity analysis of Str1 and Str2 subpopulations in LG-ESS, illustrating their potential shared ancestral origin. (B) RNA velocity analysis of Str subpopulations from HC and LG-ESS samples, showing lineage relationships between clusters. (C) Pseudotime analysis of Cluster3, 4, and 6, demonstrating differentiation paths in Str cell subpopulations. (D) Heatmap of gene expression changes during the differentiation of normal stromal fibroblasts to malignant cells. (E) Results of KEGG enrichment analysis of significantly upregulated (top) and downregulated (below)pathways during tumor cell differentiation.