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. 2024 Nov 29;14:1492465. doi: 10.3389/fonc.2024.1492465

Table 3.

PNS detection comparison between 3D LAVA_Flex and T1WI in T3 and T4 stage nasopharyngeal carcinoma.

Level T1WI
3D LAVA_Flex
T1WI Total MB test
Nerve negative positive P-value
1 mandibular nerve negative 35 0 35 0.016
positive 6 10 16
Total 41 10 51
1 maxillary nerve negative 40 0 40 0.125
positive 3 8 11
Total 43 8 51
1 cavernous sinus (CN III–V) negative 40 0 40 0.063
positive 4 7 11
Total 44 7 51
2 anterior CNs negative 25 0 25 0.031
positive 5 21 26
Total 30 21 51
1 hypoglossal nerve negative 37 0 37 0.016
positive 10 4 14
Total 47 4 51
1 jugular foramen (IX–XI nerves) negative 44 0 44 0.001
positive 6 1 7
Total 50 1 51
1 carotid space (IX–XII, primary lesion and/or lymph nodes) negative 25 0 25 0.001
positive 21 5 26
Total 46 5 51
2 posterior CNs negative 37 0 37 0.001
positive 10 4 14
Total 47 4 51
3 individual level
(all above)
negative 22 0 22 0.008
positive 7 22 29
Total 29 22 51

PNS, perineural spread; CN, cranial nerve; 3D LAVA_Flex, three-dimensional liver acquisition with volume acceleration-flexible; MB, McNemar Bowker.