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. 2024 Dec 12;15:10340. doi: 10.1038/s41467-024-53901-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Multiple overlaid single-trial excitatory postsynaptic potentials (EPSP) of one unreliable synapse (i.e., large CV of single-trial EPSP amplitudes during ‘Control’ condition, top) and one reliable synapse (i.e., small CV, bottom). Note enhancement of unreliable synapse by ‘Depol’ condition (presynaptic traces are only shown for one of the two synapses; error bars show mean ± s.d. of n = 20 single-trial EPSP amplitudes; traces were smoothed using a moving average with a 1 ms window). b Relative changes of EPSP amplitudes in response to ‘Depol’ conditions plotted against CVs of single trial EPSP amplitudes during ‘Control’ conditions (experiments with 500 and 1000 ms ‘Depol’-duration were pooled; n = 76 paired recordings; line and error band represent regression line and 95% confidence interval of a linear model). c Top, single-trial EPSPs of an exemplary synapse before and after wash-in of 100 nM DCG-IV. Bottom, averaged EPSPs. d, e Summary plots depicting decrease of synaptic reliability and increase of enhancement by subthreshold depolarizations in presence of DCG-IV (n = 7 paired recordings; two-sided Wilcoxon signed-rank tests; ACSF, artificial cerebrospinal fluid). Source data are provided as a Source Data file.