Table 2.
Characteristics and comparison of de novo PD vs Later PD
| De novo PD N = 54 |
Later PD N = 58 |
p value | |
|---|---|---|---|
| Age (years) | 67 (11.0; 42–83) | 69 (8.9, 46–84) | 0.216d |
| Female gender | 20 (37) | 32 (55) | 0.560c |
| Disease severity (HY)a | II (II–II; I–IV) | II (II–III; I–IV) | 0.114e |
| Cognition (MOCA)b | 26 (24–27; 20–30) | 25 (23–27;14–30) | 0.329e |
| Executive function (FAB)b | 16 (14–16; 3–18) | 16 (14–17; 7–18) | 0.766e |
| Motor symptoms (UPDRS)a | 21 (14–28; 8–53) | 13.5 (9–20; 1–40) | < 0.001e |
| Reactive balance (NRT)a | 0 (0–1; 0–2) | 0 (0–1; 0–3) | 0.432e |
| Dynamic balance (TG)a | 1 (0–2; 0–3) | 2 (0–3;0–3) | 0.048e |
| Mobility (TUG), sa | 9.2 (7.7–10.7; 6.4–28.4) | 10.5 (8.5–13.1; 6.8–54.1) | 0.013e |
| Dual tasking difficulties | 15 (29)n=51 | 29 (52)n=56 | 0.019c |
| CGS (10MWT), m/sb | 1.1 (1.0–1.3; 0.5–1.6) | 1.2 (0.9–1.3; 0.4–1.7) | 0.786e |
| FGS (10MWT), m/sb | 1.6 (1.3–1.9; 0.6–1.3) | 1.5 (1.2–1.8; 0.5–2.3) | 0.086e |
| FOG (FOGQsa item 3)a | 0 (0–0; 0–4)n=47 | 1 (0–3; 0–4) | < 0.001e |
| Walking ability (Walk12G)a | 7 (1–16; 0–33)n=48 | 10 (5–24; 0–42)n=56 | 0.006e |
| Number of individuals with one or more prospective falls | 5 (9) | 26 (45) | < 0.001c |
| Number of Individuals with one or more prospective near falls | 5 (9) | 19 (33) | < 0.001c |
Values are mean (SD; min–max), median (q1–q3; min–max) or n (%). Significant p values are indicated in bold
CGS comfortable gait speed, FAB frontal assessment battery, FGS Fast Gait speed, FOGQsa Freezing of Gait Questionnaire self-administered version, H&Y Hoehn and Yahr stage, MOCA Montreal Cognitive Assessment, NRT Nutt Retropulsion Test, UPDRS Unified Parkinson’s Disease Rating Scale, 10MWT 10-Meter Walk Test, m/s meters per second, TG Tandem Gait, TUG Timed Up and Go, Walk–12G 12-item generic walking scale
aHigher = worse
bHigher = better
cChi-test
dStudent’s T test
eMann–Whitney U test