Table 3.
Oxidative stress and antioxidant parameters in normal, diabetic control and diabetic treated groups.
| Parameters | Normal | Diabetic control | Diabetic treated with glimepiride | Diabetic treated with MSCs-CMT | Diabetic treated with MSCs-CMP |
|---|---|---|---|---|---|
| MDA (nmol/g. tissue) | 39.04 ± 4.34a | 128.83 ± 2.49d | 70.00 ± 5.29c | 58.92 ± 4.05bc | 50.20 ± 2.29ab |
| GSH (mmol/g. tissue) | 89.50 ± 2.25c | 38.8 ± 1.74a | 65.13 ± 3.40b | 71.25 ± 1.74b | 83.88 ± 1.06c |
| CAT (U/gm tissue) | 47.12 ± 7.20d | 115.02 ± 2.23a | 196.65 ± 2.91b | 202.65 ± 4.63bc | 218.87 ± 2.42c |
| SOD (U/gm tissue) | 36.85 ± 1.63c | 12.03 ± 0.39a | 21.70 ± 1.55b | 20.93 ± 1.79b | 31.47 ± 1.41c |
Values are expressed as Mean ± SE of 10 rats in each group. Values, which have different superscript symbols (a, b, c and d) for each parameter, are significantly different at p < 0.05. MSCs-CMT, MSCs-CM injected daily into tail vein; MSCs-CMP, MSCs-CM injected directly in pancreas. MDA, malondialdehyde; GSH, glutathione; CAT, catalase; SOD, superoxide dismutase.