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. 2024 Nov 11;265(1):14–25. doi: 10.1002/path.6363

Figure 3.

Figure 3

AMIGO2 expression is increased in CRC‐derived liver metastasis and is associated with poor patient survival. (A) Detection of AMIGO2 expression in primary tumors (PTs) and corresponding liver metastases (LMs) of the same patients (n = 7) using immunohistochemistry. These images are from patient 34 – depicted in the supplementary material, Figure S5. (B) Quantitative comparison of results from (A) (mean ± SD, two‐tailed unpaired Student's t‐test, *p < 0.05, left) and pairwise comparison of AMIGO2 expression in PT and LM in each patient (right). (C) Overall survival of patients with colon carcinoma (TCGA‐COAD cohort) with high (red, n = 68) and low (blue, n = 68) AMIGO2 mRNA expression (Kaplan–Meier plot, p = 0.032). (D) Cancer‐related survival in a prospectively collected cohort of patients with CRC with high (red, n = 146) and low (blue, n = 108) AMIGO2 mRNA expression (Kaplan–Meier plot, p = 0.038).