Table 1.
Metabolite concentrations (I.U.) and quantification error (Cramér-Rao lower bound, CRLB %) in each brain lobe and tissue type.
| Mean across volunteers | Frontal | Limbic | Parietal | Occipital | Temporal | Usable voxels | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (Standard deviation) | WM | GM | WM | GM | WM | GM | WM | GM | WM | GM | Mean % (std) |
| tCre [I.U.] | 3.34 (0.34) | 3.84 (0.04) | 3.22 (0.35) | 4.46 (0.28) | 3.30 (0.28) | 3.95 (0.28) | 3.31 (0.30) | 3.39 (0.19) | 3.09 (0.25) | 3.81 (0.19) | |
| tCre CRLB [%] | 3.25 (0.24) | 3.54 (0.41) | 3.38 (0.31) | 3.18 (0.30) | 3.21 (0.33) | 3.26 (0.26) | 3.45 (0.62) | 3.64 (0.62) | 3.42 (0.37) | 3.33 (0.26) | 73.3 (3.3) |
| NAA [I.U.] | 4.16 (0.98) | 4.51 (0.66) | 4.07 (1.01) | 5.38 (0.90) | 4.31 (0.96) | 4.84 (0.88) | 4.33 (0.98) | 4.18 (0.85) | 3.91 (0.84) | 4.35 (0.73) | |
| NAA CRLB [%] | 3.13 (0.34) | 3.55 (0.64) | 3.26 (0.33) | 3.07 (0.36) | 2.86 (0.26) | 3.05 (0.37) | 3.30 (0.54) | 3.63 (0.64) | 3.32 (0.39) | 3.32 (0.34) | 73.0 (3.5) |
| Ins [I.U.] | 3.49 (0.52) | 3.51 (0.35) | 3.65 (0.60) | 4.28 (0.48) | 3.73 (0.66) | 3.58 (0.29) | 3.74 (0.65) | 3.27 (0.57) | 3.56 (0.65) | 3.39 (0.51) | |
| Ins CRLB [%] | 5.33 (0.64) | 6.04 (0.94) | 5.29 (0.52) | 5.36 (0.42) | 5.16 (0.42) | 5.63 (0.52) | 5.38 (0.48) | 5.84 (0.50) | 5.34 (0.33) | 5.68 (0.40) | 73.0 (3.5) |
| GPC+PCh [I.U.] | 1.03 (0.10) | 0.93 (0.05) | 1.10 (0.10) | 1.24 (0.08) | 1.06 (0.11) | 0.95 (0.09) | 0.94 (0.12) | 0.79 (0.06) | 0.99 (0.07) | 0.98 (0.12) | |
| GPC+PCh CRLB [%] | 3.63 (0.34) | 4.24 (0.59) | 3.46 (0.31) | 3.56 (0.27) | 3.56 (0.29) | 3.97 (0.33) | 4.13 (0.57) | 4.59 (0.64) | 3.68 (0.29) | 3.94 (0.25) | 73.5 (3.3) |
| Glu [I.U.] | 3.86 (0.53) | 4.50 (0.29) | 3.72 (0.49) | 5.24 (0.46) | 3.86 (0.39) | 4.61 (0.39) | 3.80 (0.36) | 3.82 (0.38) | 3.50 (0.35) | 4.29 (0.44) | |
| Glu CRLB [%] | 4.51 (0.51) | 5.01 (0.85) | 4.72 (0.59) | 4.37 (0.47) | 4.31 (0.53) | 4.48 (0.55) | 4.82 (1.14) | 5.22 (1.32) | 4.80 (0.74) | 4.71 (0.64) | 72.8 (3.8) |
| Gln [I.U.] | 0.89 (0.06) | 1.24 (0.25) | 0.83 (0.06) | 1.33 (0.16) | 0.80 (0.16) | 1.08 (0.26) | 0.87 (0.22) | 0.91 (0.21) | 0.80 (0.09) | 1.07 (0.22) | |
| Gln CRLB [%] | 15.93 (2.45) | 14.81 (2.22) | 17.72 (2.68) | 14.38 (2.48) | 17.92 (4.78) | 16.22 (3.24) | 18.99 (5.14) | 18.77 (4.11) | 18.30 (2.95) | 16.45 (2.60) | 56.3 (4.6) |
| GABA [I.U.] | 1.34 (0.09) | 1.48 (0.29) | 1.34 (0.10) | 1.79 (0.37) | 1.37 (0.14) | 1.58 (0.30) | 1.33 (0.18) | 1.37 (0.18) | 1.21 (0.16) | 1.39 (0.32) | |
| GABA CRLB [%] | 8.68 (1.10) | 9.61 (1.51) | 8.86 (1.50) | 8.52 (1.74) | 8.54 (2.08) | 8.78 (1.76) | 9.48 (2.34) | 9.90 (2.22) | 9.60 (2.16) | 9.52 (2.09) | 68.3 (1.5) |
| GSH [I.U.] | 1.07 (0.24) | 1.22 (0.05) | 1.11 (0.26) | 1.45 (0.20) | 1.10 (0.20) | 1.17 (0.07) | 1.05 (0.18) | 1.00 (0.09) | 1.02 (0.17) | 1.14 (0.12) | |
| GSH CRLB [%] | 8.20 (0.88) | 8.77 (1.15) | 8.29 (0.93) | 7.96 (0.79) | 8.04 (1.00) | 8.43 (0.87) | 9.12 (2.01) | 9.80 (1.90) | 8.65 (1.23) | 8.81 (1.17) | 71.5 (3.1) |
| NAAG [I.U.] | 0.82 (0.14) | 0.39 (0.12) | 0.90 (0.13) | 0.49 (0.17) | 0.96 (0.17) | 0.34 (0.13) | 0.78 (0.16) | 0.41 (0.12) | 0.76 (0.11) | 0.35 (0.10) | |
| NAAG CRLB [%] | 14.11 (4.10) | 19.02 (5.07) | 12.43 (3.87) | 17.35 (6.07) | 12.01 (3.14) | 18.03 (5.15) | 15.51 (5.08) | 19.40 (6.62) | 15.36 (5.01) | 20.13 (6.40) | 45.3 (11.6) |
| SNR | 24.64 (4.41) | 23.67 (3.84) | 22.92 (4.50) | 24.53 (4.02) | 25.64 (4.82) | 24.73 (4.17) | 22.48 (6.13) | 21.32 (5.56) | 22.07 (4.23) | 22.40 (3.37) | |
| FWHM [Hz] | 11.43 (0.91) | 12.09 (0.77) | 11.28 (1.15) | 11.13 (1.13) | 10.21 (0.79) | 11.02 (0.84) | 11.64 (0.91) | 12.33 (1.04) | 12.26 (1.23) | 12.38 (1.22) | |
The two bottom rows present the SNR and FWHM values. The last column shows the percentage of voxels inside the brain and FoV that meet the criteria of good quality: CRLB , FWHM , SNR . The values are calculated as the average (standard deviation) across the healthy volunteers imaged by 3D ECCENTRCIC at 3.4 mm isotropic with (9 min:20 sec acquisition time).