Figure 2.

Heterologous IM/IN prime-boost immunization induces robust cross-neutralizing antibody responses against multiple variant viruses

Serum neutralizing antibody titers from immunized C57Bl/6 mice at week 6 after both prime/boost immunizations with the indicated adjuvant/antigen regimens were measured using pseudoviruses for the (A) WT, (B) B.1.617.2, (C) B.1.351, and (D) B.1.1.529 (BA.1) variants. (n = 5/group; ∗p < 0.05, ∗∗p < 0.01 by Mann-Whitney U test shown only for select groups (full statistical analysis is shown in Table S1).