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Cell viability assay with control compound 93–95 in BET sensitive wild-type and CRBN/VHL knockout RKO cell lines compared with, MZ1, dBET6 and 27. Cell antiproliferation of heterobivalent (MZ1 and dBET6) and heterotrivalent (27) BET degraders, and control compounds 93–95 after 500 pM to 10 μM treatment in wild-type, CRBN knockout, VHL knockout or CRBN/VHL double knockout RKO cell lines. EC50 values are tabulated below and in Table S6 with 95% CI.
