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Reaction conditions: (a) (i) 4 N HCl in dioxane, MeOH, r.t., 1 h, (ii) 22*, DIPEA, DCM, r.t., 16 h; (b) (i) MsCl, DIPEA, DCM, 0 °C, 20 min, (ii) r.t., 1 h; (c) 1-Boc-piperazine, DIPEA, DMSO, 90 °C, 16 h; (d) (i) 76 or 77, 4 N HCl in dioxane, DCM, r.t., 16 h, (ii) 75, DIPEA, DMF, 80 °C, 16 h.
