Scheme 7. Synthesis of Heterotrivalent BromoTag PROTAC AB3145 (97).
Reaction conditions: (a) SOCl2, DCM, r.t., 3 h; (b) (i) 4 N HCl in dioxane, MeOH, r.t., 3 h, (ii) 96*, DIPEA, DCM, r.t., 16 h.
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