Table 1.
Basic characteristics of the study cohort
| All | Women with infertility | Unaffected control individuals | |
|---|---|---|---|
| n, % | 221,838 (100) | 22,849 (10.29) | 198,989 (89.70) |
| Age, mean (SD)a | 61.40 (16.33) | 51.09 (12.91) | 62.59 (16.26) |
| BMI, mean (SD)b | 27.50 (5.72) | 27.21 (5.96) | 27.53 (5.69) |
| Given birth, n (%) | 216,469 (97.57) | 17,480 (76.50) | 198,989 (100) |
| Age at first birth, mean (SD)c | 26.20 (5.11) | 30.22 (5.77) | 25.84 (4.89) |
| Number of offspring, mean (SD) | 2.22 (1.22) | 1.50 (1.19) | 2.30 (1.19) |
| Endometriosis, n (%) | 16,618 (7.49) | 4,607 (20.16) | 12,011 (6.03) |
| PCOS, n (%) | 1,691 (0.76) | 1,011 (4.42) | 590 (0.29) |
| Leiomyoma of uterus, n (%) | 35,199 (15.86) | 3,346 (14.64) | 31,853 (16.01) |
a
Age at end of follow-up or death.
b
BMI information available only for 150,636 (67.90%) women (15,453 [67.63%] affected individuals and 135,183 [67.93%] controls).
c
Information available only for women who have given birth at least once (n = 216,469, 17,489 affected individuals and 198,989 controls).