Figure 1.

A deficiency in IL-17RA leads to increased H. pylori inflammation, lymphoid follicles, and H. pylori colonization in InsGAS mice. Total inflammation (combining chronic and acute inflammation) of gastric tissue and counts of lymphoid follicles and aggregates from the antrum and corpus were scored and combined to get the total per section of gastric tissue from mice infected for 6 weeks (A) and for 3 months (B) and their age-matched controls. See materials and method for scoring system. Significance was determined using a Kruskal-Wallis test. *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001. Levels of H. pylori colonization were determined in the mice at 6 weeks (C) and 3 months (D) post-infection by plating serial dilutions of stomach homogenate. Statistical significance was determined by a t test performed on log transformed CFU/g values. These data are representative of 2 experiments at each time point. E. Representative histological images of uninfected controls compared to mice at 6 weeks and 3 months post-infection (100× magnification). Lymphoid follicles are circled; bands of lymphocytic infiltrates are indicated by arrows.