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. 2024 Nov 26;16(1):2430421. doi: 10.1080/19490976.2024.2430421

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Figure 7. — Levels of Cybb and DNA damage increase in IL-17ra deficient mice after H. pylori infection. A. Realtime rtPCR was performed on RNA from gastric tissue to determine relative expression of Cybb. An unpaired T test was performed on data at each timepoint in panel A. B. The correlations between relative expression of Cybb, inflammation scores, disease severity are graphed with data from 3 months post-infection. Student tTest; ***p < 0.001, ****p < 0.0001. C. Correlation between log normalized expression of Cybb and log normalized expression of Ifng as determined using the PanCancer IO 360 nanostring panel are graphed. Simple linear regression analyses were performed on data in panels B and C. D. pH2AX quantification, average number of positive nuclei per high power field (HPF, average of 5 per case), and representative staining in gastric tissues (magnification is 400×). Welch’s t-test *p < 0.05.