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. 2024 Sep 26;8:100287. doi: 10.1016/j.ijpx.2024.100287

Table 2.

Model type, inputs and outputs for each process model used to develop the flowsheet model.

Unit Operation Model Inputs
Outputs
Material Properties Process Parameters
Granulation 3-D Population Balance Model
  • Powder composition

  • Powder PSD

  • Solid density

  • Liquid density

  • Liquid-to-Solid ratio

  • Wet massing time

  • Impeller speed

  • PSD

  • Porosity

  • API content uniformity

Mill 3-D Population Balance Model
  • PSD

  • Porosity

  • API composition

  • Milling Time

  • Impeller speed

  • PSD

  • Porosity

  • API content uniformity

Dissolution ODE Model
  • PSD

  • Porosity

  • API composition

  • Microstructure

  • Dissolution Curve