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. 2024 Jul 10;631(8021):654–662. doi: 10.1038/s41586-024-07623-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Time-lapse image array of cellular labile iron in pseudocolor (magenta) and cell death (cyan) propagation in erastin-treated cells. Cellular labile iron was monitored using an iron dye (FeRhoNox-1). b, Kymograph for cellular labile iron propagation from the image sequence shown in (a). The slopes of the yellow and white lines represent the speed of labile iron at the wave fronts and cell death propagation, respectively. c, d, Enhancing Fenton-mediated ROS feedback loop induces wave propagation in cells gaining ferroptosis resistance at high confluency. Time-lapse images of A549 (c) and U-2 OS (d) cells at the indicated time points after erastin treatment (10 μM) with or without ferric citrate (FC, 125 μM). Cell death is indicated by increased nuclear dye fluorescence signal. The white outlines represent the boundaries of cell death areas. Experiments were independently repeated three times with similar results. Scale bar, 300 μm (c, d).