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. 2024 Nov 22;13(23):1939. doi: 10.3390/cells13231939

Figure 1.

Figure 1

MP compounds restore DM1 cell viability and redox homeostasis. (A–C) Cell viability, intracellular calcium measurement, and ROS levels in fibroblasts derived from DM1 patients and controls. Values in DM1 are relative to controls. Dots represent mean values from control and patient individuals. Delineated dots in B represent average values from at least 30 cells, represented as non-delineated dots. (D) Cell viability of DM1 fibroblasts after treatment with 0.1 µM of indicated MP compounds for 72 h (n = 3, different individuals). (E,F) Cell viability of control and DM1 fibroblasts after treatment with 0.1, 1, and 10 µM of MP-001 and MP-002 for 72 h (n = 3). (G) Intracellular calcium measurement in same conditions as ((E); n = 3). (H) ROS levels in fibroblasts derived from DM1 patients and controls after treatment with 0.1 µM of MP-001 and MP-002 for 72 h (n = 3). ≠ p < 0.1, * p < 0.05, and ** p < 0.01.