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. 2024 Nov 22;13(23):1939. doi: 10.3390/cells13231939

Figure 2.

Figure 2

MP compounds restore DM1 cell proliferation and metabolism. (A) Quantification of the number of P-H3-positive cells in independent control and DM1 fibroblasts (n > 3) after treatment with 0.1 µM of MP-001 and MP-002 for 72 h. (B) mRNA levels of p16INK4A, p21CIP1, and p14ARF in control and DM1 fibroblasts (n ≥ 3), (C) and after treatment with 0.1 µM of MPs for 72 h. (D–F) Quantification of basal, maximal respiration, and ATP production in controls and DM1 (n > 3) fibroblasts after 0.1 µM MP compound treatment. (G) Kinetic normalized OCR response in DM1 fibroblasts in the absence or presence of 0.1 µM of MP-001 and MP-002. ≠ p < 0.1, * p < 0.05, ** p < 0.01, and *** p < 0.001.