Figure 5.

MP-002 restores molecular and functional defects in DM1 Drosophila melanogaster. (A–D) mRNA levels of indicated genes in the thorax of DM1 and control fruit flies (n = 3, each point represents a pool of six flies). (E–H) mRNA levels of indicated genes from the thorax of DM1 fruit flies in the presence of 10 and 100 µM of MP (n = 3, each datapoint comes from a pool of six flies). (I) Locomotor activity of non-treated DM1 (n = 50) flies or in the presence of 10 and 100 µM of MP (n = 50) at the indicated time points. Student t-test values are at 20 days p = 0.02 and p = 0.002, and at 25 days p <0.0001 compared to non-treated flies. ^≠ p < 0.1, * p < 0.05, ** p < 0.01, and *** p < 0.001.