Table 2.

Number (and percentage) of S- and NS- patients characterized by at least one mutation in each of the 11 signaling pathways.

Pathway	S-pts; N = 111 n (%)	NS-pts; N = 31 n (%)
Cell Cycle	50 (45)	14 (45.2)
Hippo	1 (1)	1 (3.2)
Myc	9 (8.1)	3 (9.7)
Notch	13 (11.7)	8 (25.8)
Oxidative Stress/Nrf2	16 (14.4)	7 (22.6)
PI3K	42 (37.8)	7 (22.6)
RTK/RAS/MAP	86 (77.5)	26 (83.9)
TGF-β	2 (1.8)	1 (3.2)
p53	85 (76.6)	23 (74.2)
β-catenin/Wnt	7 (6.3)	5 (16.1)
DDR *	21 (18.9)	14 (45.2)

* DDR: DNA Damage Response and Repair.