Figure 2.

Timing of the expression of candidate transcription factors in the sciatic nerves of Adar1cKO versus the controls. Analysis of the expression of Rxrg, Fosl2, Pml, Runx2, Egr1, Ddit3, Tfap2a, Tfap2b, Fosl1, and Interferon stimulated genes (ISG signature composed of Cxcl10, Isg15, Rsad2) in the sciatic nerves of the controls (grey) and HtPA-Cre; Adar1^fl/fl (Adar1cKO) mutants (blue) at embryonic day E17.5 and E18.5, newborn (P0), and post-natal day 4 (P4) by RT-qPCR. All data represent the mean ± SD. Statistical differences between the groups (n = 3 to 12 controls and n = 3 to 11 mutants) were determined using the t-test (asterisks represent p values: * p ≤ 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).