Figure 8.

Model summarizing the proposed effect of Adar1 deletion, leading to increased expression of the transcription factor. In normal Schwann cells, ADAR1 edits dsRNAs, preventing their recognition by the MDA5 sensor. Upon NC-specific Adar1 deletion, activation of the MDA5/MAVS pathway leads to aberrant overexpression/re-expression of Egr1, Tfap2a, and Tfap2b, which are repressors of the myelination process; EGR1 competes with EGR2 to control the myelination process. Red: activated and grey: not activated.