FIGURE 3.

Cardiac CLU levels are positively correlated to cardiac fibrosis induced by transverse aortic constriction. (A) Quantification by qPCR of mRNA levels of genes involved in fibrosis regulation in sham (n = 7) and TAC (n = 14) mice: Tgf‐β (transforming growth factor‐beta), Col I (collagen type I), α‐Sma (alpha‐smooth muscle Actin); and the antifibrotic Cilp (cartilage intermediate layer protein‐1). Hprt was used for normalisation. Statistical significance was determined by the Wilcoxon‐Mann Whitney test. *p < 0.05, **p < 0.01. (B) Correlation between intraventricular Clu mRNA levels and those of Tgf‐β, Col I and Cilp. Correlations were carried out by the Spearman correlation test. Results were considered statistically significant if the p < 0.05.