Table 1.
Demographic and clinical characteristics of the study cohorts.
| Total; n = 55 |
Rapid Cortisol; n = 19 |
Historical Control; n = 36 | p-Value | |
|---|---|---|---|---|
| Age (y) | 54.0 ± 10.9 | 54.8 ± 9.8 | 53.6 ± 11.5 | p = 0.71 |
| Male (%), female (%) | 73%, 27% | 79%, 21% | 69%, 31% | p = 0.54 |
| HTN diagnosis (%) | 54 (98%) | 19 (100%) | 35 (97%) | p = 1.00 |
| HTN medications (n) | 2.83 ± 0.98 | 2.9 ± 1.05 | 2.8 ± 0.95 | p = 0.72 |
| SBP (mm Hg) | 153.5 ± 19.5 | 146.8 ± 19.2 | 157.4 ± 18.8 | p = 0.067 |
| DBP (mm Hg) | 84.5 ± 13.3 | 83.9 ± 13.6 | 84.9 ± 13.4 | p = 0.79 |
| Serum potassium (mEq/L)–nadir | 3.15 ± 0.45 | 3.05 ± 0.58 | 3.19 ± 0.39 | p = 0.34 |
| MRA usage (%) | 11 (20.0%) | 5 (26.3%) | 6 (16.7%) | p = 0.48 |
| Aldosterone level (pmol/L) | 916.9 ± 565.9 | 924.8 ± 569.0 | 912.2 ± 573.2 | p = 0.94 |
| ARR (pmol/L to microIU/mL) median (IQR) | 410 [191–710] | 240.6 [153.0–704.6] | 432.5 [311.6–835.0] | p = 0.093 |
| Adrenal CT findings: | p = 0.71 | |||
| Bilateral | 14 (25.9%) | 5 (26.3%) | 9 (25.7%) | |
| Right adrenal | 10 (18.5%) | 5 (26.3%) | 5 (14.3%) | |
| Left adrenal | 26 (48.1%) | 8 (42.1%) | 18 (51.4%) | |
| Normal adrenals | 4 (7.4%) | 1 (5.3%) | 3 (8.6%) |
HTN, hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; MRA, mineralocorticoid receptor antagonists; ARR, aldosterone-to-renin ratio; IQR, interquartile range; mean ± SD.