Table 1.

miRNAs that mediate sorafenib resistance in HCC.

miRNAs	Expression	Target	Mechanism	References
miR-622	Decreased	KRAS	Activation of PI3K/AKT and MEK/ERK pathways	[114]
miR-181a	Increased	RASSF1	Activation of MAPK pathway	[115]
miR-1991-5p and let-7C	Decreased	MAPK4K3	Activation of MAPK pathway	[116]
miR-21, miR-222, miR-494	Increased	PTEN	Activation of PI3K/AKT pathway	[117,119,120]
miR-216a/217	Increased	SMAD7 and PTEN	Activation of TGFβ and PI3K/AKT pathways	[118]
miR-93	Increased	PTEN and CDKN1A	Activation of MET and PI3K/AKT pathways	[121]
miR-7	Decreased	TYRO3	Activation of PI3K/AKT pathway	[122]
miR-221	Increased	Caspase-3	Inhibition of apoptosis	[123]
miR-193b	Decreased	Mcl-1	Inhibition of apoptosis	[124]
miR-34a	Decreased	Bcl-2	Inhibition of apoptosis	[125]
let-7 family	Decreased	Bcl-xL	Inhibition of apoptosis	[126]
miR-142-3p	Decreased	ATG5 and ATG16L1	Increased autophagy	[127]
miR-122	Decreased	IGF-1R and SLC7A1	Activation of IGF signaling and increased nitric oxide	[128,129]