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. 2024 Nov 28;16(23):3996. doi: 10.3390/cancers16233996

Table 2.

Comparison of Mechanisms and Examples of Targeted Protein Degraders.

Targeted Protein Degrader Mechanism Examples of Target Protein Antitumor Activity Reference
Molecular Glues Directly bind target protein to E3 ligase GSTP1, IKZF1/3 Effective in hematologic cancers, under evaluation in NSCLC. [94,96,100]
PROTACs Possess dual-functional domains that bind both target protein and E3 ligase EGFRDel19, EGFRL858R/T790M, KRASG12C, ALK, BRAFV600E, BCL-XL Significant in both cellular and preclinical tumor models [51,52,53,54,99]