Figure 3.

Gene Ontology (GO) and KEGG pathway enrichment analysis for significant overlapped genes associated with HER2-targeted drug resistance. (A) KEGG pathway enrichment analysis by EnrichR, where the size of each point represents the number of genes in the term, and color indicates the p-value. The analysis highlights key pathways, structures, and mechanisms potentially underlying resistance. (B–D) GO analyses for molecular functions (B), cellular components (C), and biological processes (D), visualized with ClueGO in Cytoscape. In these plots, color represents different groups, and size corresponds to the number of genes in each term. All terms shown meet a significance threshold of p < 0.05.